Frontiers | Promising New Tools for Targeting p53 Mutant Cancers: Humoral and Cell-Based Immunotherapies
TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions | eLife
Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway
Frequency of p53 mutations in human cancers. (A) Schematic picture... | Download Scientific Diagram
Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome: Cell
Mutations in TP53 and other heterogeneous genes help to distinguish metastases from new primary malignancies | medRxiv
TP53 mutation spectrum in primary colorectal cancers. a Proportion of... | Download Scientific Diagram
Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by transcriptome analysis | Cell Death Discovery
Acetylation halts missense mutant p53 aggregation and rescues tumor suppression in non-small cell lung cancers - ScienceDirect
High prevalence of TP53 loss and whole-genome doubling in early-onset colorectal cancer | Experimental & Molecular Medicine
TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection - eBioMedicine
Gastrointestinal Disorders | Free Full-Text | Prognostic Impact of TP53 Mutations and Tumor Mutational Load in Colorectal Cancer
Evaluating the prognostic significance of p53 and TP53 mutations in HPV-negative hypopharyngeal carcinoma patients: a 5-year follow-up retrospective study | BMC Cancer | Full Text
TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection - eBioMedicine
Overall survival curves of patients with p53 mutation results. (A) p53... | Download Scientific Diagram
Survival of patients with p53 mutations in the DNA-binding motifs... | Download Scientific Diagram
Implications of driver genes associated with a high tumor mutation burden identified using next‑generation sequencing on immunotherapy in hepatocellular carcinoma
IJMS | Free Full-Text | Do Mutations Turn p53 into an Oncogene?
p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?
TP53 mutations predict poor response to immunotherapy in patients with metastatic solid tumors - Kim - 2023 - Cancer Medicine - Wiley Online Library
Gain of function in somatic TP53 mutations is associated with immune‐rich breast tumors and changes in tumor‐associated macrophages - Behring - 2019 - Molecular Genetics & Genomic Medicine - Wiley Online Library
Low-burden TP53 mutations in CLL: clinical impact and clonal evolution within the context of different treatment options - ScienceDirect
The p53 network: cellular and systemic DNA damage responses in cancer and aging: Trends in Genetics
Cancers | Free Full-Text | TP53 Combined Phenotype Score Is Associated with the Clinical Outcome of TP53-Mutated Myelodysplastic Syndromes
Mutational processes shape the landscape of TP53 mutations in human cancer | Nature Genetics